Medical Health Care Advices

MADRID .- So far, some research had suggested that people who work night shifts have more cancer risk than the rest of the population. The key to this phenomenon is called circadian rhythm, our internal biological clock that regulates sleep-wake cycles. And judging by the latest results of a Spanish investigation, also plays an important role in the case of tumor cells.

This clock runs from the brain activity of all organs of our body to become more active at certain times than others. And such activity is also regulated in each cell individually, except in the case of the tumor, which appears to be ‘spoiled’, according to results of a study conducted by Professor Manel Esteller.

The job of program director Epigenetics IDIBELL biomedical research institute (in Barcelona) took the cover of the latest issue of the journal Cancer Research, American Society for Cancer Research (AACR, by its initials in English) .

Working with two different types of blood cancer, leukemia and lymphoma (both cell lines and in mice), Esteller and his team have discovered that tumor cells lack a molecule responsible for regulating the rest-wake rhythm. ” That makes them wake up and be allowed to permanently stimulate the production of cancer-causing genes (oncogenes), while it blocks the production of opposites: tumor suppressor.

The molecule of the biological clock that is inactive in cancer is BMAL1 responsible for checking that certain genes are expressed rhythmically. The good news, Esteller explains in a press release, is that there are drugs on the market capable of reviving this item when it is off, so it is possible to ‘switch on’ outside to return to regain control over the genes circadian.

As pointed in their conclusions, this finding could have implications when designing treatment strategies for patients, the chemotherapy at the time of day best suited for that malignant cells are more responsive (chronotherapy). However, the next step should be to confirm their results in larger trials with patients.

Possibility Related Posts:

• What are the risk factors of cancer?
  As mentioned above, certain cancers, especially in adults, have been associated with repetitive exposure to risk factors. A risk factor is anything that may increase a person's chance of developing ...
• Childhood leukemia
  The adult leukemia in a child is sad apierta heart because leukemia is a term that refers to a group of diseases which are very complex and different, which affects white balloons. Leukemia is a malig...
• What is colon cancer?
  The colon is part of the digestive tract between the small intestine and rectum which occurs in fluid absorption from the intestinal contents and feces are formed. Colon cancer is currently an importa...
• Abnormalities of the cervix
  A malformed uterus or womb interfere with female fertility, remains the leading cause of spontaneous abortions. The incompetence of the cervix, is the fragility of the cervix, unable to stay closed un...
• Women treated with standard chemotherapy
  Ovarian Cancer  A U.S. clinical study showed that the combination treatment (Avastin) and chemotherapy significantly slows the progression of ovarian cancer. Dr. Robert Burger of Fox Chase Cancer Cent...
• The fight against cancer has improved significantly in Algeria
  The fight against cancer has improved significantly in Algeria, with the creation of new medical oncology services, said Wednesday in Algiers, Dr. Kamel Bouzid, Department Head, Centre Pierre et Marie...