Malaria
Malaria is a parasitic disease that is transmitted from human to human by the bite of infected Anopheles mosquitoes. In humans, the parasites (called sporozoites) migrate to the liver where they mature and become merozoites, which enter the bloodstream and infect red blood cells.
The parasites multiply within red corpuscles, after 48 to 72 hours, break and infect more red blood cells. The first symptoms usually occur 10 days to 4 weeks after infection, although they may appear as early as 8 days or up to 1 year thereafter. Then, symptoms of the disease occur in cycles of 48 to 72 hours.
Most symptoms are caused by the massive release of merozoites into the bloodstream, the anemia resulting from destruction of red blood cells and the problems caused by large amounts of free hemoglobin released into the circulation after the breakdown of red blood cells .
